{"id":390,"date":"2016-11-17T09:23:17","date_gmt":"2016-11-17T08:23:17","guid":{"rendered":"https:\/\/www.biogalenys.com\/passage-transmembranaire\/transintestinal"},"modified":"2020-01-29T07:25:17","modified_gmt":"2020-01-29T06:25:17","slug":"intestinal-absorption","status":"publish","type":"page","link":"https:\/\/www.biogalenys.com\/en\/transmembrane-permeation\/intestinal-absorption","title":{"rendered":"Intestinal absorption"},"content":{"rendered":"<div id=\"themify_builder_content-390\" data-postid=\"390\" class=\"themify_builder_content themify_builder_content-390 themify_builder\">\n    \t<!-- module_row -->\n\t<div  class=\"themify_builder_row module_row clearfix module_row_0 themify_builder_390_row module_row_390-0 tb_y1jc114\">\n\t    \t    <div class=\"row_inner col_align_top\" >\n\t\t\t<div  class=\"module_column tb-column col-full   first tb_390_column module_column_0 module_column_390-0-0 tb_u5yk014\">\n\t    \t    \t        <div class=\"tb-column-inner\">\n\t\t    <!-- module text -->\n<div  class=\"module module-text tb_63p6242    \">\n            <div  class=\"tb_text_wrap\">\n    <h1>INTESTINAL ABSORPTION \u2013 PERMEABILITY<\/h1>    <\/div>\n<\/div>\n<!-- \/module text -->\n<!-- module text -->\n<div  class=\"module module-text tb_ka86404    \">\n            <div  class=\"tb_text_wrap\">\n    <p>Studies of the intestinal permeation mechanism are carried out <strong>using an Ussing chamber<\/strong>.<\/p><p>This device makes it possible to determine <strong>permeability, the active ingredient\u2019s rate of transfer<\/strong><strong>, the compound\u2019s impact and physiological factors<\/strong> (composition of the gastro-intestinal environment).<\/p><ul><li>Permeability studies, type of active-passive transition with increasing doses (3 Log), P influx measurement <em>A-B<\/em> (<em>apical to basal<\/em>).<\/li><li>Specific absorption sites\u00a0 (duodenum, jejunum, ileum, colon).<\/li><li>Impact of P-glycoprotein: <em>P <\/em><em>efflux measurement B-A (basal to apical).<\/em><\/li><li>Impact of excipients.<\/li><li>Fraction absorbed by humans (F%).<\/li><\/ul><p>Our protocols make it possible to <strong>study kinetics<\/strong> following application on the mucosal apical side (A) or the mesenteric serous side (B).<\/p><p>Our protocols also make it possible to <strong>precisely determine the permeability of the human intestine<\/strong>.<\/p><p>(P<em>eff<\/em>: effective permeability), based on the calibration of a series of remedies with variable permeability (providing the P<em>eff<\/em> and the absorption rate as a percentage, FA%).<\/p>    <\/div>\n<\/div>\n<!-- \/module text -->\n\t<div  class=\"themify_builder_sub_row module_subrow clearfix sub_row_0-0-2 tb_z9bd020\">\n\t    \t    <div class=\"subrow_inner col_align_top\" >\n\t\t\t<div  class=\"sub_column module_column col4-2  first sub_column_post_390 sub_column_0-0-2-0 tb_nb8l704\"> \n\t    \t    \t        <div class=\"tb-column-inner\">\n\t\t    <!-- module text -->\n<div  class=\"module module-text tb_twcf447    \">\n            <div  class=\"tb_text_wrap\">\n    <ul><li>Provides information to assess new preparations<\/li><li>Slow-release oral form<\/li><li>Immediate release form<\/li><li>Improves absorption<p>\u00a0<\/p><p><em>\u00a0<\/em><\/p><\/li><\/ul>    <\/div>\n<\/div>\n<!-- \/module text -->\n\t        <\/div>\n\t    \t<\/div>\n\t\t<div  class=\"sub_column module_column col4-1 middle sub_column_post_390 sub_column_0-0-2-1 tb_oqvs540\"> \n\t    \t    \t        <div class=\"tb-column-inner\">\n\t\t        <!-- module image -->\n    <div  class=\"module module-image tb_nxfr844   image-top  \">\n\t                <div class=\"image-wrap\">\n                            <img loading=\"lazy\" decoding=\"async\" width=\"148\" height=\"199\" src=\"https:\/\/www.biogalenys.com\/wp-content\/uploads\/2017\/03\/ussing2copie2-1.jpg\" class=\" wp-post-image wp-image-693\" alt=\"Ussing chamber picture\" \/>            \n                        <\/div>\n            <!-- \/image-wrap -->\n        \n        \n        <\/div>\n    <!-- \/module image -->\n\t        <\/div>\n\t    \t<\/div>\n\t\t<div  class=\"sub_column module_column col4-1  last sub_column_post_390 sub_column_0-0-2-2 tb_5np9476\"> \n\t    \t    \t        <div class=\"tb-column-inner\">\n\t\t        <!-- module image -->\n    <div  class=\"module module-image tb_bnpt449   image-top  \">\n\t                <div class=\"image-wrap\">\n                            <a href=\"https:\/\/www.biogalenys.com\/wp-content\/uploads\/2017\/04\/Ussing-2D.jpg\"\n                   class=\"lightbox-builder themify_lightbox\"                   >\n                                               <span class=\"zoom ti-search\"><\/span>\n                                        <img loading=\"lazy\" decoding=\"async\" width=\"900\" height=\"775\" src=\"https:\/\/www.biogalenys.com\/wp-content\/uploads\/2017\/04\/Ussing-2D.jpg\" class=\" wp-post-image wp-image-1676\" alt=\"Ussing-2D\" srcset=\"https:\/\/www.biogalenys.com\/wp-content\/uploads\/2017\/04\/Ussing-2D.jpg 900w, https:\/\/www.biogalenys.com\/wp-content\/uploads\/2017\/04\/Ussing-2D-300x258.jpg 300w, https:\/\/www.biogalenys.com\/wp-content\/uploads\/2017\/04\/Ussing-2D-768x661.jpg 768w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/>                <\/a>\n            \n                        <\/div>\n            <!-- \/image-wrap -->\n        \n        \n        <\/div>\n    <!-- \/module image -->\n\t        <\/div>\n\t    \t<\/div>\n\t\t    <\/div>\n\t<\/div><!-- \/themify_builder_sub_row -->\n\t\t        <\/div>\n\t    \t<\/div>\n\t\t    <\/div>\n\t    <!-- \/row_inner -->\n\t<\/div>\n\t<!-- \/module_row -->\n\t\t<!-- module_row -->\n\t<div   class=\"themify_builder_row module_row clearfix fullwidth_row_container module_row_1 themify_builder_390_row module_row_390-1 tb_ip7u070\">\n\t    \t    <div class=\"row_inner col_align_top\" >\n\t\t\t<div  class=\"module_column tb-column col4-2  first tb_390_column module_column_0 module_column_390-1-0 tb_ov4z007\">\n\t    \t    \t        <div class=\"tb-column-inner\">\n\t\t    <!-- module text -->\n<div  class=\"module module-text tb_vdgb240    \">\n            <div  class=\"tb_text_wrap\">\n    <h2>Biopharmaceuticals<\/h2><ul><li>pKa, LogP, LogD<\/li><li>Study of the physiological solubility of active ingredients<\/li><li>Stability study in physiological environments<\/li><li>Determining the BCS biopharmaceutical classification<\/li><li>Effects of raw material particle size<\/li><\/ul>    <\/div>\n<\/div>\n<!-- \/module text -->\n\t        <\/div>\n\t    \t<\/div>\n\t\t<div  class=\"module_column tb-column col4-2  last tb_390_column module_column_1 module_column_390-1-1 tb_nl8z808\">\n\t    \t    \t        <div class=\"tb-column-inner\">\n\t\t    <!-- module text -->\n<div  class=\"module module-text tb_ltoe707    \">\n            <div  class=\"tb_text_wrap\">\n    <p><em>Our Biogalenys standard range for determining human permeability<\/em><\/p>    <\/div>\n<\/div>\n<!-- \/module text -->\n    <!-- module image -->\n    <div  class=\"module module-image tb_9qpo004  image-top  \">\n\t                <div class=\"image-wrap\">\n                            <a href=\"https:\/\/www.biogalenys.com\/wp-content\/uploads\/2017\/04\/correlation-1.jpg\"\n                   class=\"lightbox-builder themify_lightbox\"                   >\n                                               <span class=\"zoom ti-search\"><\/span>\n                                        <img loading=\"lazy\" decoding=\"async\" width=\"900\" height=\"669\" src=\"https:\/\/www.biogalenys.com\/wp-content\/uploads\/2017\/04\/correlation-1.jpg\" class=\" wp-post-image wp-image-1678\" alt=\"correlation curve\" srcset=\"https:\/\/www.biogalenys.com\/wp-content\/uploads\/2017\/04\/correlation-1.jpg 900w, https:\/\/www.biogalenys.com\/wp-content\/uploads\/2017\/04\/correlation-1-300x223.jpg 300w, https:\/\/www.biogalenys.com\/wp-content\/uploads\/2017\/04\/correlation-1-768x571.jpg 768w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/>                <\/a>\n            \n                        <\/div>\n            <!-- \/image-wrap -->\n        \n        \n        <\/div>\n    <!-- \/module image -->\n\t        <\/div>\n\t    \t<\/div>\n\t\t    <\/div>\n\t    <!-- \/row_inner -->\n\t<\/div>\n\t<!-- \/module_row -->\n\t<\/div>\n\n\n","protected":false},"excerpt":{"rendered":"<p>INTESTINAL ABSORPTION \u2013 PERMEABILITY Studies of the intestinal permeation mechanism are carried out using an Ussing chamber. This device makes it possible to determine permeability, the active ingredient\u2019s rate of transfer, the compound\u2019s impact and physiological factors (composition of the gastro-intestinal environment). Permeability studies, type of active-passive transition with increasing doses (3 Log), P influx [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":387,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-390","page","type-page","status-publish","hentry","has-post-title","has-post-date","has-post-category","has-post-tag","has-post-comment","has-post-author",""],"_links":{"self":[{"href":"https:\/\/www.biogalenys.com\/en\/wp-json\/wp\/v2\/pages\/390","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.biogalenys.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.biogalenys.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.biogalenys.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biogalenys.com\/en\/wp-json\/wp\/v2\/comments?post=390"}],"version-history":[{"count":0,"href":"https:\/\/www.biogalenys.com\/en\/wp-json\/wp\/v2\/pages\/390\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.biogalenys.com\/en\/wp-json\/wp\/v2\/pages\/387"}],"wp:attachment":[{"href":"https:\/\/www.biogalenys.com\/en\/wp-json\/wp\/v2\/media?parent=390"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}