TRANSOCULAR

Studies of transscleral/transcorneal permeation with modified Franz diffusion cell assembly or Ussing chamber (Biogalenys).
Reverse transport study, impact of P-glycoprotein (cornea).
Pharmacokinetic studies and distribution of topical preparations (cornea, lens, aqueous humour, retina, sclera).
Stability and enzymatic hydrolysis studies (determining Vi Km and Vmax).
Pharmokinetic studies following intra-vitreous administration or deposit (vitreous humour, choroid, retina).

Application